Acta
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Delayed and prolonged coma after acute disulfiram overdose

2009, N° 3 (Vol. 109/3) p.231-234
S. Lemoyne, J. Raemaekers, J. Daems and L. Heytens
Dienst Intensieve Zorg, Sint-Augustinus, Wilrijk; Psychiatric Centre Bethanië, Zoersel, Belgium

Abstract:
We report the case of a 35 year old man presenting with a delayed and prolonged coma due to an intentional overdose with disulfiram without simultaneous alcohol ingestion. The clinical features – comprising a severe toxic encephalopathy with coma and convulsions, in combination with a quadriparesis outlasting the loss of consciousness – are summarized, and the physiopathology is reviewed.

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